Fiorentina have the opportunity to go eight points clear of the relegation zone, but the injury crisis intensifies as Lazio welcome back Mattia Zaccagni and Patric.
It kicks off at the Stadio Artemio Franchi at 19.45 UK time (20.45 CEST).
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You can follow all the build-up and action as it happens on the Liveblog.
With the other games already played and negative results for Cremonese and Lecce, it means a victory here would send Fiorentina flying into 15th place, above all creating an eight-point gap from the drop zone.
LONDON, ENGLAND – APRIL 09: Paolo Vanoli, Head Coach of ACF Fiorentina, reacts during the warm up prior to the UEFA Conference League 2025/26 Quarter-Final Leg One match between Crystal Palace FC and ACF Fiorentina at Selhurst Park on April 09, 2026 in London, England. (Photo by Eddie Keogh/Getty Images)
However, the team is stretched thin by the strain of the Conference League, losing the quarter-final 3-0 to Crystal Palace on Thursday night at Selhurst Park.
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The second leg is coming up this week, with Moise Kean, Fabiano Parisi, Marco Brescianini, Niccolò Fortini, Luca Lezzerini and Tariq Lamptey still out injured.
Paolo Vanoli also cannot count on suspended Albert Gudmundsson and Nicolò Fagioli, while Manor Solomon and Rolando Mandragora are not at 100 per cent.
Roberto Piccoli therefore has to lead the attack once more, with Cher Ndour in midfield, Jacopo Fazzini and Jack Harrison in support.
FLORENCE, ITALY – MARCH 12: Roberto Piccoli of ACF Fiorentina in action during the UEFA Conference League 2025/26 round of 16 first leg match between ACF Fiorentina and Rakow Czestochowa at Stadio Artemio Franchi on March 12, 2026 in Florence, Italy. (Photo by Gabriele Maltinti/Getty Images)
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Lazio had won three games in a row before their 1-1 draw with Parma, and are still aiming to close within a point of Bologna in eighth place.
Maurizio Sarri also has a lot of problems to deal with, because Daniel Maldini and Adam Marusic are the latest additions to the absentee list, joining Ivan Provedel, Mario Gila, Samuel Gigot and Nicolò Rovella.
The surprise is that Zaccagni, Toma Basic and Patric are thrown straight back into the starting XI after recovery, while Fisayo Dele-Bashiru is back on the bench.
Matteo Cancellieri is also preferred to Gustav Isaksen.
ROME, ITALY – JANUARY 04: Matteo Cancellieri of SS Lazio competes for the ball with Juan Jesus of SSC Napoli during the Serie A match between SS Lazio and SSC Napoli at Stadio Olimpico on January 04, 2026 in Rome, Italy. (Photo by Marco Rosi – SS Lazio/Getty Images)
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Fiorentina vs. Lazio line-ups
Fiorentina: De Gea; Dodò, Rugani, Ranieri, Gosens; Ndour, Mandragora, Fabbian; Fazzini, Harrison; Piccoli
Lazio: Motta; Lazzari, Romagnoli, Provstgaard, Nuno Tavares; Taylor, Patric, Basic; Cancellieri, Dia, Zaccagni
