12th February 2025 – (Hong Kong) Professor Yuen Kwok-yung, Chair of Infectious Diseases at the University of Hong Kong, has raised concerns about the rare and sudden death of a young, healthy oncologist at Princess Margaret Hospital (PMH) following a suspected cluster of Shiga toxin-producing Escherichia coli (STEC) infections. Speaking on a radio programme today, Professor Yuen described the case as “highly unusual,” noting that the bacteria rarely cause severe complications in individuals without underlying health conditions.
The infection cluster involves three oncologists at PMH, all of whom developed gastrointestinal symptoms, including diarrhoea, over the past week. One of the doctors, a man in his 30s, succumbed to the illness just three days after the onset of symptoms, despite treatment with antibiotics.
Professor Yuen stated that while investigations are focused on STEC as the likely cause, other possibilities, such as co-infections with viruses, chemical exposure, or autoimmune conditions, cannot yet be ruled out. Genetic sequencing is underway to determine the precise cause of death. “Even if the deceased was infected with STEC, the severity of his condition is highly atypical,” he remarked.
Environmental sampling has been conducted in the shared office and restroom facilities used by the affected doctors, as these are suspected transmission points. Although STEC bacteria typically die quickly on dry surfaces, disinfection efforts prior to sample collection may complicate the investigation.
Professor Yuen emphasised the need for thorough pathology and genetic analyses, noting that the rapid progression of the deceased doctor’s illness left limited biological samples for study. He also indicated that an autopsy may be required, pending the family’s consent, to provide definitive answers.
The outbreak has prompted PMH to enhance disinfection protocols and increase monitoring among staff for gastrointestinal symptoms. Investigators are also exploring potential sources of contamination, such as food or environmental factors, as the affected doctors reportedly shared a meal in the hospital’s break room.
