New Definition of Long COVID Sets Course for Unified Care and Research

Long COVID as an infection-associated chronic condition persisting for at least 3 months after COVID-19 infection.

Image credits: Unsplash

A significant development aimed at addressing the multifaceted challenges posed by Long COVID. A report by the National Academies of Sciences, Engineering, and Medicine (NASEM), commissioned by the Administration for Strategic Preparedness and Response and the Office of the Assistant Secretary for Health, emphasizes the urgent need for a standardized approach to recognize Long COVID as an infection-associated chronic condition persisting for at least three months after COVID-19 infection. Jerry Krishnan, MD, PhD, Professor and Associate Vice Chancellor for Population Health Sciences at the University of Illinois Chicago, and member of the committee shares NASEM’s process in clarifying their newfound definition.

“Long COVID is an “infection-associated chronic condition” (IACC), which can be triggered by viruses, bacteria, funding, or parasites. Examples of other IACCs include Lyme-associated chronic illnesses or various disorders after Giardia infections. The 2024 NASEM committee hopes that the use of IACC in the definition of Long COVID can promote research across what previously were considered largely different diseases, allowing for cross-disease learning and actionable insights.”

This definition has been coined through various terms being proposed for chronic conditions after the initial infection with SARS-CoV-2 during the COVID-19 pandemic, including Long COVID.

“We now know that Long COVID can present in different ways in different people – including which symptoms, when they start, whether they are persistent or fluctuate in severity or frequency, impact on a person’s life, and how long they last. So, the 2024 NASEM definition acknowledges the heterogeneity of trajectory and severity.”

Main Takeaways

  1. The NASEM has proposed a unified definition for Long COVID, defining it as an infection-associated chronic condition persisting for at least three months after COVID-19 infection, aiming to standardize diagnosis and treatment approaches.
  2. The development of this definition involved extensive engagement with over 1,300 stakeholders, including patients, caregivers, healthcare providers, and policymakers, ensuring diverse perspectives were incorporated into the process.
  3. The new NASEM definition acknowledges current gaps in understanding Long COVID, prompting a call for continued research to improve diagnostics, understand its underlying causes, and develop effective treatments, with flexibility to adapt as new knowledge emerges.

Recognizing these complexities, the NASEM report underscores the importance of broad stakeholder engagement and interdisciplinary dialogue in formulating the new definition. The committee responsible for the report engaged over 1,300 participants, prioritizing diverse perspectives including those of patients.

“NASEM had an extensive approach to soliciting input from various stakeholders, including patients and other individuals across multiple sectors in focus groups, via an online questionnaire and portal for public comments, and a 2-day hybrid in-person and virtual symposium. A key lesson learned from these multi-stakeholder engagements is that we have much to learn from patients with Long COVID and their families and other caregivers, and healthcare providers on the front lines,” according to Krishnan.

The new definition of Long COVID is intended to serve multiple purposes, encompassing clinical care, eligibility criteria for health services, insurance coverage, disability benefits, educational and workplace accommodations, public health strategies, social services, policymaking, epidemiological surveillance, and both private and public research initiatives. It aims to enhance public awareness and education, particularly among patients, families, and caregivers.

“The 2024 NASEM definition relied on the current state of evidence and input from various stakeholders. At this point, there is a paucity of information about the pathogenesis of Long COVID and there are no known biomarkers of the disease process or processes that we call “Long COVID.”The diagnosis of Long COVID therefore relies exclusively on history and the symptoms that patients report may have multiple etiologies,” explains Krishnan.

According to the report, the new definition of Long COVID aims to serve diverse purposes, including clinical care, health service eligibility, insurance coverage, disability benefits, educational and workplace accommodations, public health strategies, social services, policymaking, epidemiological surveillance, and research initiatives.

“By standardizing the terminology and use of a simple to understand phrase (“Long COVID”), has the potential to accelerate the research that is already underway. The 2024 NASEM Long COVID Definition is by design inclusive but allows researchers flexibility in designing studies that are consistent with the definition while also sufficiently specific to meet the study objectives. The 2024 NASEM committee recognizes that research is needed to fill several gaps in our knowledge about Long COVID, including a better understanding of the epidemiology (risk factors, trajectory of symptoms), pathogenesis (underlying cause(s), and validated biomarkers to facilitate diagnosis), and treatments that are safe and effective,” states Krishna.

All in all, The National Academies report marks a critical step toward addressing the complex landscape of Long COVID by advocating for a cohesive definition that unifies efforts across healthcare, policy, and research domains. As stakeholders consider these recommendations, the hope is to mitigate the challenges faced by Long COVID patients and foster a more coordinated approach to understanding and managing this persistent health challenge.

Krishna finishes by stating, “Research is needed to improve the sensitivity and specificity of laboratory tests to identify individuals who have been previously infected – months or years ago. We also solicit input from all stakeholders as they apply the 2024 NASEM Long COVID Definition and recommend the definition be updated when relevant new knowledge is available or in three years, whichever occurs first.”

References
1. News Release. Federal Government, Clinicians, Employers, and Others Should Adopt New Definition for Long COVID to Aid in Consistent Diagnosis, Documentation, and Treatment. National Academies. Published June 11, 2024. Accessed June 19, 2024. https://www.nationalacademies.org/news/2024/06/federal-government-clinicians-employers-and-others-should-adopt-new-definition-for-long-covid-to-aid-in-consistent-diagnosis-documentation-and-treatment

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九市速遞:華南地區首發現賴氏恐龍化石 - 20250215 - 港聞 - 每日明報

九市速遞:華南地區首發現賴氏恐龍化石 – 20250215 – 港聞 – 每日明報

港聞 2025年2月15日星期六 港聞二 法官陳嘉信再涉司法抄襲 獲裁不成立 判辭九成搬原告裁斷屬自撰 調查小組:應囑勿再 火燒人案判決被指偏頗 裁判官林希維投訴不成立 記協春茗訂場「電力不穩」遭臨時取消 鄭嘉如:問酒店受壓否答「技術問題」 轉地點2·24辦 體育園最後演練 推「離場易」助分流 明日模擬要員到訪 網頁實時顯示路線需時 鄭雁雄籲中資參建北都 稱港久經磨難 「終於有中國香港樣子」 岑浩輝訪港 李家超:將拓「聯線同遊」 NJZ門票出錯 ComplexCon退款 1月旅客按年增24% 疫後單月新高 可口可樂無人機 情人節夜空「舉杯」 依托咪酯刊憲列毒品 2萬警已受訓用太空油試紙 輔導團體:短期杜絕太樂觀 學校可設三層識別機制 男警被蓋嬰虐兒囚14月 官:助入睡說法不合理 填海修例被憂失司法制衡 甯漢豪:現制一直行政決定 反恐二案 辯:搜前多人篋拖鄰室 證物警員否認插贓 區議員培訓班 麥美娟提青年工作可做更好 盧寵茂:最壞打算收回中大醫院 議員多支持順延借貸 關注院方3年後續無力還款 中大醫院行政總裁馮康7月退休 盧煜明:已獲數名高質素接任人選 浸大:倘撥款減3%至5%可承擔 再削有影響 中醫醫院條例草案刊憲 三爺孫命案 九旬死者為蕃田村原居民 村長:遷出廿年 每年回村祭祖領錢 流感活躍度仍高 當局籲打針 內地女子涉學歷造假再提堂 港推體育產業化 澳洲體委會CEO:精英同需資助 「奧運項目亦難商業化 需政府支持」 讚體育園配套好 「未來吸澳洲盛事」 脅迫印傭性交 僱主性騷擾賠18萬 吃布冧藉機非禮5歲孫 七旬翁囚18月 許金山提上訴 九市速遞:中大深圳成立AI學院 大勢所趨 醫學院大一融入人工智能教學 九市速遞:華南地區首發現賴氏恐龍化石 九市速遞:廣州海珠擬設直升機航線 直飛港澳 九市速遞:深國際仲裁院去年近1.5萬商事案新高 灣區手記:節儉辦會 /文:尚東美 【Emily】情人節曬畫冧太太 李家超:感恩有你 湖邊牽手畀人影相畫埋畫 【Emily】副廉政專員出席聯國會議 介紹香港國際廉政學院 【Emily】獻計滅赤 陳仲尼一拳滅尺 【Emily】明年人口普查 只抽一成填長問卷 【Emily】積金局新春聚會 眾「前輩」捧場  Source link

New Samsung Galaxy A26 renders leak

Back in November a set of CAD-based renders leaked showing the upcoming Samsung Galaxy A26, and today we have some fresh official-looking renders portraying the device in three different colorways. It’s unclear if these are all the hues in which the A26 will be offered. As you can see, Samsung continues to change the design

佐丹奴盈警料全年純利最多跌四成 罷免前主席兼港人北上等拖累 (19:04) – 20250213 – 即時財經新聞

公司認為,海灣阿拉伯國家合作委員會及東南亞市場表現穩定,溢利減少主要由於於期內按股東要求(即周大福控股提出罷免時任主席兼行政總裁劉國權)而召開股東特別大會所產生的一次性開支;分佔南韓合營公司的溢利減少;中國內地的可比店舖銷售額出現負增長,此乃由於過往於中國內地缺乏對品牌及產品作投資,致使陳舊存貨水平較高;及香港業務受港人北上消費熱潮影響而轉弱、消費券計劃終止及缺乏租金補貼。 集團指,正按其對業務經營所在市場洞悉的趨勢實施相應的策略,致力推動收益增長、節省成本及提升盈利能力。 佐丹奴大股東周大福控股在去年曾要求召開股東特別大會,要求包括罷免公司主席劉國權董事及行政總裁職務,最終成功踢走劉國權,並委任非執行董事曾安業為公司主席,又另外委任鄭家純女兒鄭志雯、兒子鄭志亮為非執董,委任Colin Currie為執董。 其他報道 領展房地產投資最近成立  為日後參與基金管理業務鋪路 「鱷王」警告特朗普政府:將赤字削減至3% 否則該辭職 許正宇:整合60間港會計所名單 助內企利用港會計專業走出去 永嘉料全年虧損收窄至約6000萬元 下半年轉賺2600萬元 Tesla電池零件供應商中偉股份擬赴港上市 最多籌39億元 全日沽空金額增38% 恒生中國企業增36倍 Linkedln推「Future Ready Program」計劃 解決人才短缺及技能差距 藍十字調查:年輕人出行普遍未買旅遊保險 香港音樂平台Fireverse完成A輪融資250萬美元 估值達3000萬美元 標普:本港寫字樓租金今年料續下行 甲廈租金回到2012年水平 港股倒跌 恒指跌43點 北水轉流出 成交3794億 4個月最多 阿里成交400億元 新地將軍澳三大商場推出「將軍澳泊車賞」 本田、日產放棄合併談判 承諾繼續進行戰略合作 阿里、快手成交股數逾5年最多 景順:DeepSeek提高市場對內地企業創新信心 目前估值是買入點 華夏香港月底推港元數字貨幣基金 為亞太首隻 滬指尾市跌勢加劇 以日中低位收市 克而瑞︰若萬科無法自我造血償債 只靠資產出售難打破局面 阿里蔡崇信確認阿里與蘋果合作 匯豐保險推醫療保健服務月費計劃 可享普通科視像診症優惠 瑞銀:今年中國公司在亞洲上市交易中佔比將上升 恒指升幅擴大至逾600點科指彈4% 百度快手阿里健康漲逾一成 OpenAI Altman承諾推GPT5後 免費用戶可無上限使用ChatGPT Source link

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